Why do long acting beta2 agonists (found in Advair, Symbicort) increase the risk of Asthma related death?
Why do these long acting bronchodialators increase the risks of asthma death? I understand that a problem is broncho-dialation is increased, remaining inflamation may be left untreated, thus the need to combine these medicines with inhaled corticosteriods. But does anyone know WHY else there might be a connection between LABA's and Asthmatic severity?
Answer by Jerry S
Because some people treat them as resue inhalers when they are NOT. They have a much longer onset campared to resue inhalers like Albuterol and Levalbuterol and some people not knowing this take them for acute attacks and it does not help immediatly increasing the risk of death. If you have a severe acute attack you do need steroids too, but in the ER they usually give them IV with drugs such as salumedrol, decadron, or celestone as well as inhaled steroids.
This is why people must take Advair and Symbicort as directed. They are preventitive meds and are supposed to be taken Twice a day no matter what. Even if you are feeling fine.
The LABA may also take up the beta receptor sites in the lungs if taken before a short acting agonist there may be less sites to bind to rendering it less effective.
Answer by ptheoc
All men are NOT created equal dispite what it says. Diff people rect differently to some medications. It has nothing to do with not taking the medicine properly.
In 1984, I think it was, a large part of the doctors in California went on strike over something for four days. The death rate went DOWN by 80%! 80%!
Pharmacutical companies want to make money. To do this they sell drug that wil (A) help some people. (B) Not help some people. and (C) Kill as few a % of the population as possible. That unfortunately is not a joke either.
Answer by Frustrated RT
ptheoc: In 1984, I think it was, a large part of the doctors in California went on strike over something for four days. The death rate went DOWN by 80%! 80%!
That's your argument. that's pretty pathetic. I've read some of your other answers as well and I am not impressed to say the least.
I agree with Jerry S. His answer seems a lot more plausible.
Orignal From: Why do long acting beta2 agonists (found in Advair, Symbicort) increase the risk of Asthma related death?
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